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ea0035p776 | Obesity | ECE2014

Application of LC–MS and CE–MS based metabolomics to study type 2 diabetes development in lean, overweight and obese humans

Ciborowski Michal , Kretowski Adam , Adamska Edyta , Citko Anna , Waszczeniuk Magdalena , Wilk Juliusz , Golonko Anna , Pliszka Justyna , Lipinska Danuta , Goscik Joanna , Rusak Magdalena , Godzien Joanna , Barbas Coral , Gorska Maria

The risk of type 2 diabetes mellitus (T2DM) development is related to BMI, therefore this disease mainly occurs among overweight (OW) and obese (OB) people. However lean (L) individuals may also suffer from T2DM. The evolution of T2DM is a multistep process and starts with insulin resistance (IR), which may evolve into pre-diabetic state i.e.: impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In up to 70% of patients pre-diabetic state evolves into T2DM. ...

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Application of LC–MS and CE–MS based metabolomics to study type 2 diabetes development in lean, overweight and obese humans

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